To Itch or Not to Itch - Part 2
Article by HairlossTalk.com
May 20, 2004
Part two covers Nizoral and the Propecia trials, How to get rid of your inflammation, and how inflammation can affect the success of your treatment regimen...
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Part 1 of this Article |
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To
itch or Not to Itch? - Part 1
Topics: What is Inflammation? |
Why do you itch with Hair Loss? | Anti-inflammatory
in the Propecia Trials |
Why no Nizoral in the Propecia Trials?
Some people wonder why the Propecia trial did not use Nizoral as the shampoo of
choice. The main problem with this was that Nizoral shampoo was not readily available
when the trial started. If the Propecia trial was taking place today when Nizoral
is readily available it probably still would not be used. Although Nizoral is
officially used for treating dermatitis and combating mild scalp fungal infections,
the active ingredient (ketoconazole) has known anti
androgen properties and this may have some positive effect on hair growth.
The objective of arranging a trial to test Propecia was to examine the effects
of the drug, not the effects of Nizoral.
In one small clinical study it was even suggested that the
actions of Nizoral on hair growth were equivalent to the effects of 2% minoxidil
(4).
Nizoral and Tgel are not made by Merck, the makers of Propecia, so they are
not likely to promote the merits of combining Nizoral or Tgel with using Propecia
even though there may be advantanges to the consumer in doing so. However,
many dermatologists will recommend to their patients the use of Propecia, Nizoral
and Tgel. You can use all three in a combined regimen. Nizoral should
not be used more than twice a week. Other days you can use Tgel and normal shampoo
in rotation. The only problem with Nizoral and Tgel is that they can be quite
drying to the hair. You can remedy this with a separate conditioner.
Nizoral, the god of hair loss Shampoo's
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Without exception, nizoral is the most successful shampoo on the market today
at not only controlling the itch, but any underlying inflammation you may not
be able to detect, while simulatneously helping stimulate minor hair growth.
No other shampoo we know of can do this. Tgel is another good alternative, but
no regimen should be without Nizoral. You can get Nizoral in the shampoo section
of any grocery store, typically at the end, next to the Rogaine. We suggest
all our users make use of it once every 3 days. Apply it immediately as you
get in the shower, and let it soak for the duration of your shower. After a
few weeks your itching should be gone, and we suggest continuing with it indefinitely.
Its truly the only shampoo out there that can do what it does.
In the natural products isle at the local store you will also find aloe vera
or tea tree lotions. These products can work well, but of course they only reduce
the inflammation and do not treat the underlying cause of the inflammation.
If you stop using them and the underlying promoter of the irritation is still
present, then the inflammation will come back. One word of warning, anti-inflammatory
products do seem to have the potential to promote folliculitis (let’s
call it scalp acne) when they are used for a long time. It is ironic that an
anti-inflammatory product should do this, but it does seem to occur in some
people. If folliculitis develops just stop using the product and it should go
away.
Inflammation and the Effectiveness of your Regimen
At this stage in our understanding of inflammatory cells and their influence
on hair growth we don’t know which inflammatory signals are good and which
are bad. However, it is reasonable to say that if your scalp is irritated/inflamed
AND you see you are losing more hair, then the kind of skin irritation/inflammation
you have is certainly not helping to grow hair and may even be exacerbating
it. The best thing for you to do is make sure you are using Nizoral shampoo
once every 3 days as part of your regimen. Its ability to reduce any noticeable
(and unnoticeable) inflammation will only benefit your progress, and the effectiveness
of your treatment regimen. Having antiandrogenic properties itself, it may also
help stimulate hair growth, and it is literally the only shampoo on the store
shelves today that can do this.
All the above applies more or less equally to men and women. The nature of
inflammation in female AGA has not been investigated in any detail, but it is
quite likely that at least some women have a big problem with scalp inflammation
and this may be contributing to their hair loss. Skin biopsies from women with
AGA can show much the same kind of cellular inflammation seen in biopsies from
men. Women are also susceptible to dermatitis whether contact dermatitis or
seborrheic dermatitis - just like men. If dermatitis seems to be a problem then
medicated shampoos like Nizoral nad Tgel are just as valid for use by women
as by men.
In Conclusion
Some say AGA and inflammation are inextricably linked and part of the same
problem. Some say they are two separate conditions but often found together
in the same person because they are so common. Some say inflammation is a primary
cause of hair loss and others say the inflammation is just a secondary response
to something else that is causing the hair loss. This is all very confusing
and the scientific evidence to prove who is right and who is wrong is not likely
to be produced for a long time. However, if you have hair loss and scalp irritation
together it makes sense to look into reducing scalp inflammation. No one can
say for sure if it will really help hair growth but it should do no harm. Is
it possible that eliminating scalp irritation might stop hair loss completely
for a while? – possibly!
1) Sueki H, Stoudemayer T, Kligman AM, Murphy GF. Quantitative
and ultrastructural analysis of inflammatory infiltrates in male pattern alopecia.
Acta Derm Venereol. 1999 Sep;79(5):347-50.
2) Jaworsky C, Kligman AM, Murphy GF. Characterization
of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis.
Br J Dermatol. 1992 Sep;127(3):239-46.
3) Young JW, Conte ET, Leavitt ML, Nafz MA, Schroeter AL. Cutaneous immunopathology
of androgenetic alopecia. J Am Osteopath Assoc. 1991 Aug;91(8):765-71.
4) Pierard-Franchimont C, De Doncker P, Cauwenbergh G,
Pierard GE. Ketoconazole shampoo: effect of long-term use in androgenic alopecia.
Dermatology. 1998;196(4):474-7.
- Legitimate Proven Treatments for Men: Overview
- Other Helpful Treatments for Men: Overview
- Legitimate Proven Treatments for Women: Overview
- Other Helpful Treatments for Women: Overview
HLT
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