Hair Loss Treatments
Hair Loss & Alopecia Information, Support, and Treatments
Page 1 of 4 123 ... LastLast
Results 1 to 10 of 31
  1. #1
    Senior Member Jacob's Avatar
    Join Date
    Apr 2005
    Posts
    3,503

    5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum

    http://www.expanscience-ingredients....en/avocuta.pdf

    http://www.expanscience-ingredients....ocuta-hair.htm

    (27 volunteers - cream containing 2% active ingredient- 3 theoritical weeks)

    1. Sebum samples were taken before and after the treatment (applications twice a day) using a Sebufix® F16 patch, enabling secretion levels to be assessed. A visual examination was performed by a dermatologist (applying scores on a 1 to 5 scale) as well as a digital analysis. A reduction of 34% was recorded in this score, a mean reduction of 69% in cumulative total lipid stain surface area, thus demonstrating the reality of a sharp slowdown in the activity of the sebaceous glands.

    2. Using a scoring scale of 0 to 9 and six criteria, the dermatologist assessed the condition of the volunteers' skins before and after treatment. That condition improved sharply in all cases.

    3. The volunteers were able to confirm the clinical results by giving their own assessment of the effectiveness of the cream (% positive opinions):

    Improvement in greasy appearance of hair: ---- 78%
    Soothing effect on irritation: -------------------------- 63%
    Reduction in dandruff: --------------------------------- 67%
    Normal human fibroblasts are treated for 24 hours, either with Serenoa repens (a pharmaceutical active ingredient
    known to inhibit 5- reductase) or with 5 Avocuta®, in the presence of radiomarked testosterone. The formation of
    dihydrotestosterone (DHT) from testosterone is directly correlated to 5- reductase activity and its quantity is proportional
    to the quantity of radioactivity measured.

    The addition of Serenoa repens clearly reduces the activity of 5-
    reductase and therefore the quantity of DHT synthesised. At the same
    concentrations, 5 Avocuta® is more effective at inhibiting the activity of
    5- reductase (-49% for 100 ?g/ml).

    Since DHT is a powerful androgen stimulating the sebaceous glands,
    5 Avocuta® appears to be an excellent active substance for improving
    seborrheic conditions.
    Shampoo containing 1% 5  Avocuta® applied every two days by 27 volunteers (3 weeks).

    1/ The cumulative surface area of lipid spots decreased by an average of 69% (13 subjects), demonstrating a marked
    slowing down of sebaceous gland activity.

    2/ The seborrhea was reduced by approximately half, while the stinging,
    pruritus, erythema and desquamation that frequently accompany
    seborrheic conditions had practically disappeared.

    3/ Lastly the volunteers confirmed these results:
    - improvement of the greasy appearance of hair (78%),
    - soothing effect on irritation (63%)
    - reduction of dandruff (67%)

  2. #2
    Senior Member Jacob's Avatar
    Join Date
    Apr 2005
    Posts
    3,503

    Re: 5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum


  3. #3
    Senior Member Bryan's Avatar
    Join Date
    May 2002
    Location
    Houston, TX USA
    Posts
    8,671

    Re: 5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum

    That's all well and good, but what does it have to do with hair loss?
    1) No, damnit, finasteride for hairloss was NOT an "accidental discovery".
    2) No, you do NOT have to use minoxidil and Retin-A at the same time.
    3) No, washing your skin does NOT make it produce more sebum.

  4. #4
    Senior Member Jacob's Avatar
    Join Date
    Apr 2005
    Posts
    3,503

    Re: 5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum

    I'm sorry...did I make some sort of claim above?

    Ppl in these forums..who actually use things...are interested in ingredients/products geared towards scalp health..even sebum reduction.

  5. #5
    Senior Member Bryan's Avatar
    Join Date
    May 2002
    Location
    Houston, TX USA
    Posts
    8,671

    Re: 5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum

    In all seriousness, you should post that over on acne.org. Those people are desperate to find something that will reduce their sebum production!
    1) No, damnit, finasteride for hairloss was NOT an "accidental discovery".
    2) No, you do NOT have to use minoxidil and Retin-A at the same time.
    3) No, washing your skin does NOT make it produce more sebum.

  6. #6
    Senior Member Jacob's Avatar
    Join Date
    Apr 2005
    Posts
    3,503

    Re: 5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum

    Since you're already signed up and posting there..for whatever reason...go for it

  7. #7
    Senior Member Bryan's Avatar
    Join Date
    May 2002
    Location
    Houston, TX USA
    Posts
    8,671

    Re: 5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum

    Okay...I'll do it! (Although I may just direct them over here to read all that stuff.)
    1) No, damnit, finasteride for hairloss was NOT an "accidental discovery".
    2) No, you do NOT have to use minoxidil and Retin-A at the same time.
    3) No, washing your skin does NOT make it produce more sebum.

  8. #8
    Senior Member
    Join Date
    Mar 2011
    Posts
    169

    Re: 5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum

    Arch Enemies

  9. #9
    Senior Member Bryan's Avatar
    Join Date
    May 2002
    Location
    Houston, TX USA
    Posts
    8,671

    Re: 5? Avocuta-inhibits the activity of 5 ? reductase/anti-sebum

    Well, I'm still holding-off on posting on the other site, because I'm having a fair amount of trouble finding a source of this "5? Avocuta". I did find an acne product which claims to have it as an ingredient, but I'd like to have a bit more than just that. I'll try again a little later...
    1) No, damnit, finasteride for hairloss was NOT an "accidental discovery".
    2) No, you do NOT have to use minoxidil and Retin-A at the same time.
    3) No, washing your skin does NOT make it produce more sebum.

  10. #10

Similar Threads

  1. anti-sebum
    By andrei_eremenko in forum Antiandrogens - Propecia, Dutasteride, etc.
    Replies: 6
    Last Post: April 13th, 2009, 12:54 PM
  2. Common Anti-Androgens can promote AR activity via ARA55
    By LinuxCavalier in forum New Research, Studies, and Technologies
    Replies: 0
    Last Post: June 5th, 2008, 01:02 PM
  3. 5 alpha reductase and sebum production
    By norwood4 in forum Men's General Hair Loss Discussions
    Replies: 4
    Last Post: October 17th, 2007, 01:52 PM
  4. Azelaic acid/Zinc combo inhibits type I 5-alpha reductase
    By HLTguest in forum Alternative Treatments
    Replies: 4
    Last Post: December 21st, 2006, 11:31 PM
  5. Anti-dht + Anti-Estrogen ?The solution against side effects?
    By Koros in forum Men's General Hair Loss Discussions
    Replies: 4
    Last Post: July 22nd, 2004, 02:54 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •