Malignant murine melanoma (BL6-F10) cells convert arachidonic acid primarily to PGD2, PGF2alpha, PGE2, PGI2 in descending order of magnitude. Supplementation with 1-10 microg/ml vitamin E succinate resulted in a significant (P < or = 0.05) decrease in PGD2 levels at vitamin concentrations of 3, 5, 7 and 10 microg/ml respectively
, while PGF2alpha levels were significantly decreased at 1, 3, 5 (P < or = 0.05), 7 and 10 microg/ml (P < or = 0.01) vitamin E succinate. BL6-F10 cells supplemented with 7 and 10 microg/ml vitamin E succinate showed a marked increase in PGE2 levels with a significant increase occurring at 10 microg/ml (P < or = 0.025). PGI2 levels followed a similar trend to PGE2 with a significant increase (P < or = 0.05) occurring at 10 microg/ml.