Propecia's devastating effect on neurohormones

[Enden]

Take a look at the chart. Example; allopregnanolone was reduced by more than 300% (!!!) after 4 months treatment.

5 mg finasteride a day, is just as potent as 1 mg a day.

[Wuffer]

Damn, that's actually some scary stuff..

Do you have more info on how these numbers were obtained? Was it just from one patient, or an average from a number of patients?

Have you had your allopregnanolone levels tested, Enden (or is having it tested viable?)

[Enden]

Download- and take look at the study which is attached in the first post. The numbers are the average result. I don't remember how many patients that they used in the study, but it was a group of men.

I wanted to check my neurohormones, but my doctor wouldn't refer me to a specialist...

[Enden]

Take a closer look at allopregnanolone. In one case, the level was reduced by 876.5%!!!

[Wuffer]

Oh right, I didn't see that.

Are neurohormones actually tested from your brain tissue, or is it from a spinal tap or something?

I don't know much about hormones, but I assume allopregnanolone can not easily (or at all) be supplemented.

[Enden]

Oh right, I didn't see that.

Are neurohormones actually tested from your brain tissue, or is it from a spinal tap or something?

I don't know much about hormones, but I assume allopregnanolone can not easily (or at all) be supplemented.

I have no idea. I guess they draw some blood from your arm like they do with most other tests. I think the paper states how they did this in the study. Allopregnanolone is made from progesterone, so a progesterone cream (they're available OTC) could increase the allopregnanolone level.

[Enden]

Low level of allopregnanolone has been linked to MS as well.

Individuals with multiple sclerosis (MS) may have impaired production of important neurosteroid molecules in their brains, so replacement therapy could be helpful, researchers said.

Autopsy findings from 16 MS patients showed high expression of micro-RNA molecules in white matter that suppress enzymes responsible for neurosteroid synthesis, particularly allopregnanolone, according to Christopher Power, MD, of the University of Alberta in Edmonton, and colleagues.

The researchers also confirmed that levels of allopregnanolone and other steroids were depressed in the MS patients' white matter, they reported online in Brain.

(...)

and as if that wasn't enough

(...)

Although neurosteroids had not previously attracted much attention in MS research, their involvement should not be a surprise, Power and colleagues argued.

These substances "exert diverse effects on neural cell function and survival in the brain," they wrote. In particular, allopregnanolone is recognized as a regulator of GABAergic function, which in turn affects behavior and survival of glial cells and neurons.

Allopregnanolone also appears to diminish proinflammatory activity of at least some immune cells, the researchers indicated. But unlike glucocorticoids, it lacks broad immunosuppressive effects -- "hence, this and related molecules might provide new therapeutic options, devoid of the side-effects of common immunosuppressive therapies," Power and colleagues wrote.

Brain Steroids Found Lacking in MS

[6730]

does Allopregnalone levels rise once u get off the drugs

is there any irreversible damage?

[TravisB]

Merck is a huge, HUUUUGE pharma. I actually think that they can get away with everything that isn't killing people. It's virtually impossible for Propecia to not have any negative effect on your organism when it ****s up your hormones so much. Some people can not feel any symptoms, but as it's documented by many people on the internet, the tactile sides can come out after many years (even 10 years), or just after you drop the drug. I just don't see how can you alter your hormones for so many years, and then not be screwed up.

However, I'm considering Finasteride myself, but I don't have any certainty that something better will come out in the next 5 years, and I certainly don't want to be on Fin for a very long time!

[Prop]

However, I'm considering Finasteride myself, but I don't have any certainty that something better will come out in the next 5 years, and I certainly don't want to be on Fin for a very long time!

but even if a new drug come out with promising result, will be advisable use it without any long term study?
new drugs new risks

unfortunately after my fina exeperience i became too much cautious