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  1. #1
    Senior Member Fanjeera's Avatar
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    Jun 2008
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    This is it: I am infertile!

    Just got my sperm test. The doctor is stunned and so am I. How is it possible? What to do next?

    Results (december 2009):
    sperm capacity -- 2,83 ml (norm: > 2ml);
    viscosity -- 1 cm (norm: <2)
    sperm count -- 33 millions/ml (norm: >40 millions/ml);
    sperm whole count -- 93,4 millions;
    mobility -- 0% fast, 16% moderate, on spot 19%, immobile 65% (norm: >25% fast)
    morphology -- 0% normal (norm >10%), 99% head defect, 58% middle part, 61% tail defect, 1% development errors.

    How's that? I can't believe it's possible taking a pill so wide spread for such a little time... but it is. The character of my semen changed within a day or so: it's amount decreased by like 2/3, it became transparent and somewhat watery and jelly, its volatility became nonexistent. Any suggestions what to do next?
    Immediately after getting the results I called my GP and was able to get an endocrinologist appointment right away. She told me that she doesn't believe low FSH could cause it, because the sperm count itself is pretty high and the defects are coming from the testicles. I as well showed her my hormone test results and she found nothing to worry about, though my estradiol and LH are above the reference ranges. Umm... so finasteride affects the testicles somehow?

    All my blood tests:
    1) Done in October 2009:
    S-LH 7.03 U/I (1.7 - 8.6)
    S-FSH 2.63 U/I (1.5 - 12.4)
    S-Estradiol 99.5 pmol/l (28-156)
    S-Testosterone 26.3 nmol/l (9-27.8)
    2) Done in November 2009:
    SHBG 28 nmol/l 1,3-71
    LH 11 U/l 1,7-8,6
    FSH 2,49 U/l 1,5-12,4
    Prolactin 150 mU/l 98-456
    Estradiol 162 pmol/l 28-156
    Testosterone 17,7 nmol/l 9-27,8
    3) Done in March 2010:
    FSH 1,72 (0,7 ... 11,1 U/L)
    LH 3,93 (0,8 ... 7,6 U/L)
    Estradiol 244 (<206 pmol/L)
    Testosterone 36,6 (nmol/L)
    DHEAS 9,74 (2,2 ... 15,2 mmol/L)
    Androstenedione 16,5 (2,1 ... 10,8 nmol/L)

    My latest sperm test (March 2010):
    Capacity 4,57 ml (>2)
    Sperm count 35 M/ml (>40)
    Whole count 159,9 M
    Mobility 5% fast (>25%), 21% moderate (>50% the last 2 together), on spot 19%, immobile 55%
    Morphology 4% normal (>10%), 91% head defect, 51% middle part defect, 22% tail defect, 2% development errors (<160% the last 4 together)


    As you can see my sperm has got a little better, but my estradiol values are still growing. Any suggestions?

  2. #2
    Senior Member Nene's Avatar
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    Oct 2009
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    Jersey City, NJ
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    1,303

    Re: This is it: I am infertile!

    Quote Originally Posted by Fanjeera
    Just got my sperm test. The doctor is stunned and so am I. How is it possible? What to do next?

    Results:
    sperm capacity -- 2,83 ml (norm: > 2ml);
    viscosity -- 1 cm (norm: <2)
    sperm count -- 33 millions/ml (norm: >40 millions/ml);
    sperm whole count -- 93,4 millions;
    mobility -- 0% fast, 16% moderate, on spot 19%, immobile 65% (norm: >25% fast)
    morphology -- 0% normal (norm >10%), 99% head defect, 58% middle part, 61% tail defect, 1% development errors.

    How's that? I can't believe it's possible taking a pill so wide spread for such a little time... but it is. The character of my semen changed within a day or so: it's amount decreased by like 2/3, it became transparent and somewhat watery and jelly, its volatility became nonexistent. Any suggestions what to do next?
    Immediately after getting the results I called my GP and was able to get an endocrinologist appointment right away. She told me that she doesn't believe low FSH could cause it, because the sperm count itself is pretty high and the defects are coming from the testicles. I as well showed her my hormone test results and she found nothing to worry about, though my estradiol and LH are above the reference ranges. Umm... so finasteride affects the testicles somehow?
    You don't know for sure what caused it. I'm not saying it wasn't fin, but then again it could've been anything.

  3. #3
    Senior Member Axl_Rose's Avatar
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    Feb 2008
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    Paradise City.
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    27
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    408

    Re: This is it: I am infertile!

    Interesting.
    "Drink'n'drive white lightning faster baby
    Takin' your last ride
    Now better be so careful or you'll be dead before you time
    Sorry you took mother's car now"

  4. #4
    Senior Member
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    Dec 2006
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    1,841

    Re: This is it: I am infertile!

    High LH WITH over range estradiol is strange. Normally high estradiol inhibits LH/Fsh production. Are you sure you got the right E2 Test done? If so, try some arimidex to get E2 down to normal range.

  5. #5
    Senior Member Boondock's Avatar
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    May 2009
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    Re: This is it: I am infertile!

    Dang that's pretty crazy. I can only suggest that your doctor is on the right track. There has never been much of a suggestion that finasteride affects sperm production, in the long-term, in the way that it seems to have affected you. Generally sperm quality is the result of either low FSH, or some malfunction in the testicles. It's conceivable that finasteride could have a knock-on effect to cause problems in the former, but it's hard to see how it would have affected the testicles.

    Seeing and endocrinologist and/or urologist is probably your best bet to get to the bottom of this.

  6. #6
    Senior Member
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    Re: This is it: I am infertile!

    You need to find your

    5a-thf/thf ratio. Usually offered by Urine testing.

    This will reflect intracellular 5AR activity. If its normal then its unlikely finasteride is having any lingering effects in your body.

    it's not always usefull to just check DHT levels.

    This is because DHT is not a viable indicator of peripheral 5-alpha-reductase activity, because the ability of 5-alpha-reductase to process testosterone is not the first biochemical reaction to suffer, when 5-alpha-reductase is downregulated.

  7. #7
    Senior Member Fanjeera's Avatar
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    Re: This is it: I am infertile!

    Quote Originally Posted by Boondock
    Dang that's pretty crazy. I can only suggest that your doctor is on the right track. There has never been much of a suggestion that finasteride affects sperm production, in the long-term, in the way that it seems to have affected you. Generally sperm quality is the result of either low FSH, or some malfunction in the testicles. It's conceivable that finasteride could have a knock-on effect to cause problems in the former, but it's hard to see how it would have affected the testicles.

    Seeing and endocrinologist and/or urologist is probably your best bet to get to the bottom of this.
    Like it was suggested by the doctor... I wanted to do it myself.
    Anyway, I went straight to an endo and asked, if low FSH could cause it. She told me that low FSH was very good for fertility and that the problem has to be in the testicles. Isn't that the other way round?

  8. #8
    Senior Member Boondock's Avatar
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    Re: This is it: I am infertile!

    ^ I'm no endocrinologist, by my assumption was that testicular dysfunction was usually accompanied by high FSH, because the brain is trying its hardest to ramp up sperm production in face of what seems to be quite low output.

  9. #9
    Senior Member Fanjeera's Avatar
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    Re: This is it: I am infertile!

    That's what I also think and that's how it probably is. Which means finasteride affects the pituitary and the brain...
    But the doctor told me that the sperm count in 1 ml isn't so much under the normal value, so that means the brain is doing its job and added that the malformations to the spermatosoids can only come from the testicles. I have 0 normal sperms and 0 fast sperms...
    I still doubt it her theory though. I still want to know what is FSH's and pituitary's actual effect on spermatogenesis.

  10. #10
    Senior Member
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    Oct 2009
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    Re: This is it: I am infertile!

    I feel really bad for you mate

    ****ing finasteride bull****.

    I've been applying it topicaly for over a month now via xandrox.. Il stick it out for another 5 months along with the other stuff i do and if it dosn't work, **** it. THOUGH, my hair dosn't appear to have got any worse over the past month lol. Maintanence much? who knows lol.

    I don't think i can even chance taking it internally now. Good luck my friend

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