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  1. #1

    HISTOGEN (Regenica HGEN-001) - Launch date 2015.

    http://www.histogeninc.com/products/hgen_001.htm

    HGEN-001 HGEN-001 is a proprietary liquid formula created by infusing the soluble chemicals secreted by the newborn fibroblasts with the liquid media. It is the first naturally stabilized and bioactive formulation of wnt proteins and growth factors, offering exceptional opportunities for applications including research tools and biologics products.
    [*]...The formula contains naturally stabilized and bioactive wnt proteins and activity [*]...The formula contains naturally secreted growth factors [*]...HGEN-001 is soluble and injectable [*]...The formula requires no purification process [*]...Capabilities for Hair growth

    Hair loss affects 35 million men and 21 million women in the United States.

    One of Histogen's significant applications for HGEN-001 is its utilization as an injectable for hair growth. The combination of wnt proteins and growth factors making up HGEN-001 has been shown to both stimulate resting hair follicles and induce new follicle formation.

    In May 2007, these findings were substantiated by research performed by Dr. George Cotsarelis, which offered further evidence that these growth factors and proteins in combination lead to a significant increase in the creation of new hair follicles in mice.

    Histogen's injectable for hair growth will be undergoing clinical trials, and launch is planned for 2015.



  2. #2

    Re: REGENICA (Histogen HGEN-001) - Launch date 2015.

    http://www.histogeninc.com/products/regenica.htm

    ReGenicaTM ReGenicaTM is a proprietary liquid formula created by the culturing of newborn fibroblasts in an embryonic-like environment and then harvesting the naturally secreted growth factors, anitoxidants and other synergistic bioproducts that are produced. It is the first naturally stabilized and bioactive formulation of wnt proteins and natural cofactors - offering exceptional opportunities for applications including research tools and as a natural additive in products.

    The formula contains naturally stabilized and bioactive wnt proteins with activity
    The formula contains naturally secreted growth factors
    ReGenicaTM is soluble and can be in both a topical or injectible format. injectible
    The formula requires no purification process
    Capabilities for Skin & Hair Care

    ReGenicaTM is currently being researched as an additive to cosmeceutical products, with applications from post-resurfacing treatments to commercial anti-aging products.

    The liquid formulation contains a complex mixture of actives, including human growth factors such as Keratinocyte Growth Factor, soluble human ECM such as collagen, and natural cellular antioxidants which supports the epidermal stem cells that renew skin throughout life.

    In May 2008, an evaluation of ReGenicaTM's as a treatment for post-laser patients was completed. Preliminary 'proof of concept' results from this first evaluation suggest that topical application of a skin gel supplemented with ReGenicaTM can provide overall improved visible re-epithelialization of post ablative laser facial skin, and thereby accelerate patient recovery, keeping superficial cutaneous side effects to a minimum. More details can be found within the news announcement at: http://www.histogeninc.com/aboutus/news_events.htm#8"

    Additional studies are planned for late 2008, including further evaluation of ReGenicaTM as a treatment for post-resurfacing as well as preliminary evaluation of ReGenicaTM for anti-aging applications.

    Histogen is also evaluating ReGenicaTM as an active ingredient for hair care products such as shampoos and conditioners. The Company anticipates ReGenicaTM's interaction with hair follicles will help hair to grow thicker, stronger and more flexible.

    Capabilities for Hair growth

    Hair loss affects 35 million men and 21 million women in the United States.



    One of Histogen's significant applications for ReGenicaTM is its utilization as an injectable for hair growth. The combination of wnt proteins and growth factors making up ReGenicaTM has been shown to both stimulate resting hair follicles and induce new follicle formation.

    In May 2007, these findings were substantiated by research performed byDr. George Cotsarelis, which offered further evidence that these growth factors and proteins in combination lead to a significant increase in the creation of new hair follicles in mice.

    Histogen's injectible ReGenicaTM for hair growth will begin clinical trials in Q4 2008, and launch is planned for 2015.

  3. #3

    Re: REGENICA (Histogen HGEN-001) - Launch date 2015.

    http://www.azcentral.com/arizonarepu...kinco1019.html

    Company picks Valley to develop skin products
    Oct. 19, 2008

    The Arizona Republic

    Sunshine and skin damage have prompted a San Diego biotechnology company to expand in Arizona to develop a line of anti-aging skin products.

    Histogen Inc. has opened a Tempe office and plans to begin selling three new skin-care products in the first quarter of 2009.

    The company said it uses a stem-cell-like technology to foster a skin product derived from skin discarded from infants after circumcisions.

    The company wants to parlay revenue collected from the sale of aesthetic products to fund research in areas such as cardiovascular and wound healing.

    It's the same playbook sketched out by other Arizona biotechnology companies such as Tucson-based Niadyne Development: develop anti-aging skin products backed by science to raise cash while focusing on a bigger prize of health research.

    The Tempe division is called Histogen Aesthetics.

    President Lawrence Rheins said the company chose Arizona to launch its aesthetics business due to the Phoenix-area's large network of dermatologists and plastic surgeons focused on cosmetic and anti-aging procedures as well as the state's growing biotechnology hub.

    "Everybody who lives here gets photo (sun) damage," said Rheins, who previously served as a director at Hill Top Research in Scottsdale and an assistant dermatology professor at the University of Cincinnati. "There is a real need for these types of products because of the desert climate and the intense sun."

    Histogen CEO Gail Naughton was the co-founder of Advanced Tissue Sciences, a former San Diego biotech company that had a promising skin-patch technology to treat burns and wounds.

    The company eventually filed bankruptcy amid heavy debt and a struggle to get Food and Drug Administration approval for a key product.

    Naughton, now a dean of the college of business administration at San Diego State University, has reloaded with Rheins and several of her former Advanced Tissue colleagues.

    Of Histogen's first 25 employees, 18 worked together at Advanced Tissue, Rheins said.

    "It is clearly the reason we were able to start as fast as we were able to," he said.

    Histogen's Tempe office has four employees, with plans to expand to about 20 workers as the company launches its line of skin products targeting baby boomers and others. The positions will mainly be sales and marketing.

    Rheins said the company expects its non-prescription products will be sold by plastic surgeons and dermatologists and distributed by a Tempe company, Secure Medical. Secure Medical CEO John Rao also sits on the board of Histogen, and Secure Medical is an investor.

    Histogen's products will be made from an ingredient the company calls ReGenica, which can be used for skin, hair and nail care.

    The company said its technology mimics the embryo, allowing the growth of protein-rich material that is similar to what is found in young skin.

    Rheins said the company's initial products will include a gel that can be applied to skin after laser resurfacing. It also will unveil anti-aging lotions that are applied day and night.

    Earlier this year, Histogen unveiled a kit to grow stem cells, called BioNuesis.

    The Tempe division expects to expand with other skin offerings such as dermal fillers or treatments for skin conditions such as acne or rosacea.

    Rheins said Histogen has no plans to conduct research at its Tempe office, but the company may conduct clinical trials here.

    The parent company, which formed last year, believes the technology can be used to eventually have many beneficial therapeutic uses, including regenerating cells that can help treat cardiovascular patients and heal wounds.

  4. #4
    Senior Member hairsucks's Avatar
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    Re: REGENICA (Histogen HGEN-001) - Launch date 2015.

    Great post, another treatment in the pipeline. The more the better, one of them has to work, one day!

    Cheers Chrome, where the hell do you find all this stuff?

  5. #5

    Re: REGENICA (Histogen HGEN-001) - Launch date 2015.

    hairsucks,

    In the newspaper article above it says:

    "Histogen Inc. has opened a Tempe office and plans to begin selling three new skin-care products in the first quarter of 2009."

    I have emailed Histogen to ask if this is true and,more importantly, will these include the same/similar technology. If its the same/similar then we only have to wait a few months to try a topical that *may* help. Obviously it won't be as effective as the hairloss injections due in 7 years time, but atleast we can try it with "needling" and, you never know, we may have a decent treatment out of this within a few months. Will be interesting to see their reply anyway. Worth an email anyway imho - just in case

    cheers, chrome.

  6. #6
    Senior Member hairsucks's Avatar
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    Re: REGENICA (Histogen HGEN-001) - Launch date 2015.

    Could be very interesting, Keep us posted with your email Chrome, thanks again!

  7. #7
    Senior Member sphlanx2006's Avatar
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    Re: REGENICA (Histogen HGEN-001) - Launch date 2015.

    chrome thx for keeping us up to date! As for histogen...the more products on the line, the better thats a sure thing!
    Quote Originally Posted by Gunner
    Perhaps as entertainment we could hire Dr Lee to do some juggling whilst riding a unicycle.

  8. #8
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    Re: REGENICA (Histogen HGEN-001) - Launch date 2015.

    They have a product launched already - BioNuesis. viewtopic.php?f=32&t=48526
    The trouble on these hair loss forums is that people are emotionally involved, and often just want to `believe' that a particular thing offers `hope'. This is why it is often easy for real science to be overlooked in MPB, but in the long term it is only `real' science that will provide the answers! -SFoote
    http://hair-less.blogspot.com/

  9. #9
    Senior Member hairsucks's Avatar
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    Re: REGENICA (Histogen HGEN-001) - Launch date 2015.

    bornthisway,

    I read that link and I still have no idea what that product is? well, I know it's the "Only All-Human Stem Cell Culturing Kit" but how does it help with hairloss? by stem cell growth?

    I think I need to read up on stem cells.

  10. #10
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    Re: REGENICA (Histogen HGEN-001) - Launch date 2015.

    Your posts are all awesome chrome - cheers for taking the time to post things like this.

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