Hair Loss Treatments
Hair Loss & Alopecia Information, Support, and Treatments
Search
I want information on..
Hair Loss Pictures
"I am mostly fortunate as I am in my late 40's and only now am I beginning to experience hair loss. It is on the front hairline and upto the centter part line, plsu general thinning..."
Men's Hair Loss Network
Check out the latest photo blogs from other guys treating their hair loss. Set up your own profile today!
Men's Hair Loss Network
pagal123
Men's Hair Loss Network
Abilash...
Men's Hair Loss Network
trentbr...
Men's Hair Loss Network
uncanny...

View all Men's Hair Loss Blogs
Hair Transplant Network
Our newest members who've gone the Transplant route. See their progress graft by graft and upload your own Transplant Bio!
Men's Hair Loss Network
adrian30
Men's Hair Loss Network
olly1983
Men's Hair Loss Network
tdog
Men's Hair Loss Network
dabra

View the Hair Transplant Network
Women's Hair Loss Network
The newest women who have set up photo blogs in our network. Join today and share your story!
Women's Hair Loss Network
Adeline...
Women's Hair Loss Network
michcar...
Women's Hair Loss Network
Ellis
Women's Hair Loss Network
dizzy

View all Women's Hair Loss Blogs


Transplants Replacement
0 New posts today
0 People currently Posting »

hair loss alopecia
Hair Loss News
Alopecia hair loss Chat
0 People currently chatting »
Support Chat Schedule Find out when we are having our next chat gathering. Find out when we are having our next chat gathering.

Previous Chat Transcripts Get valuable information from previous in the in the hair loss chat room. the hair loss chat room.

Join the Chat
replacement transplants
You are here:  Home » News & Research » Hair Loss News Center » Effect of Minoxidil on Apoptosis in Dermal Papilla Cells
Effect of minoxidil on proliferation and apoptosis in human dermal papilla cells.
Authors:
Jun-Kyu Oh, Ji-Hyun Han, Kyu-Han Kim,
Jin-Ho Chung, Kwang-Hyun Cho, Hee-Chul Eun.
Department of dermatology, Seoul national university, Seoul, Korea.

Study Information and Results:

Minoxidil promotes hair growth and prolongs the duration of anagen phase, but the exact mechanism of these effects has not been known.

Recently, it was reported that testosterone and dihydrotestosterone inhibited proliferation and induced apoptosis in dermal papilla cell and this might be another pathomechanism of androgenetic alopecia. In this study we investigate whether minoxidil promotes proliferation and inhibits apoptosis in cultured human dermal papilla cell.

We used MTT assay to evaluate the influence of minoxidil on proliferative activity of dermal papilla cells at 0, 10 -8 , 10 -7 , and 10 -6 M after 5 days, and also estimated the phosphorylation of extracelluar signal-regulated kinase (ERK) by immunoblotting at 0, 10 -7 , and 10 -6 M after 1, 24, and 48 hours.

To evaluate the influence of minoxidil on apoptosis, the expression of bcl-2 and bax was detected by immunoblotting at 0, 10 -7 , and 10 -6 M after 24 and 48 hours. In MTT assay proliferative activity of DPC was increased as a concentration-dependent manner and phosphorylation of ERK was also increased with minoxidil, which shows that the proliferative effect of minoxidil is induced by phosphorylation of ERK.

The expression of bcl-2 was increased and the expression of bax was decreased with minoxidil after 24 hours, which shows antiapoptotic effect of minoxidil occurs through bcl-2/bax pathway.

This study shows that minoxidil has proliferative and antiapoptotic effects on dermal papilla cells, and this may be one of the mechanism by which minoxidil acts on hair growth.

HLT
© HairlossTalk.com - All Rights Reserved.
The content found here is not intended as a substitute for professional medical advice.
For permission to duplicate any content, please Contact Us.
Make sure you're Subscribed to the Newsletter! We never share your info.
News Search
I want information in news on...
Sign Up
HairlossTalk Monthly Newsletter
Instant Notifications
Don't wait for the newsletter! Register to be notified as soon as we publish a new article to the News Center.
Hair Loss Alopecia
Genetic Basis for cause of Alopecia Areata A genetic basis for triggering Alopecia Areata discovered by Dr. Angela Chr... »
Aldara as a Treatment for Alopecia Areata? Efficacy of imiquimod in the treatment of alopecia areata... »
transplants replacement
hair loss