Effect of HEM-13/HDC on Hair Growth

Article by BJ Shin, SW Ahn, WJ Tak, BI Ro.

Authors:
BJ Shin, SW Ahn, WJ Tak, BI Ro.
Dept. of Dermatology, College of Medicine, Chung Ang University, Seoul, Korea.

Study Information and Results:

We studied to investigate the clinical improvement of herbal extract mixtures in the patients with androgenetic alopecia.

Total 76 patients (treatment group: 62, placebo group: 14, male: 63, female: 13) with androgenetic alopecia received topical application of HEM-13/HDC hair tonic or placebo for 6 months and then all of them received topical application of HEM-13/HDC hair tonic for 3 months.

The efficacy was evaluated by hair counts, patient self-assessment, global photographic assessment and phototrichogram of the bald area in a circle of 1cm in diameter. Hair count and image analysis was performed before treatment, at 3, 6, 9 month after treatment respectively to compare the hair shaft diameter and hair density.

At baseline, mean total hair counts in the tested area were 63.4 in the treatment group and 64.7 in the placebo group. At month 6, patients in the placebo had a decrease (mean ± SE) in hair counts of 1.3 ± 0.4 hairs. At month 9, patients in the treatment had an improvement (mean ± SE) in hair counts of 3.5 ± 0.7 hairs respectively (p<0.05), and had a significant increase in hair diameter (p<0.05). Over 85% of the subjects showed improvement of clinical symptoms and increase of hair growth.

These data support that HEM-13/HDC hair tonic results in favorable effects on hair growth of patients with androgentic alopecia. In Mice, Hair growth was assessed by photographic method. In both the HEM-13/HDC and minoxidil groups, the hair grew into the normal state in 3 weeks but in the vehicle group, hair grew only to 1/3 the state of HEM-13/HDC group. In the animal study, it is as effective as or more effective than minoxidil. Any skin reactions were not observed in clinical and animal studies. We concluded that HEM-13/HDC has a hair growth stimulating effect.

Conclusions:

These herbs in the form of a treatment known as HEM-13/HDC Hair Tonic were tested on human subjects for a period of 9 months, and on Mice subjects along with Minoxidil. In Human subjects, 85% showed a cessation of loss or hair growth. In mice models, the herbal treatment had a similar rate of success as minoxidil.

HLT

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