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» Effects of Finasteride on Apoptosis and the Hair Cycle
Effects of Finasteride on Apoptosis and the Hair Cycle
Article by Department of Physiology and Biophysics, Miami, FL, USA.Apoptosis is the process by which normal healthy follicle cells begin to disintegrate into particles that are ultimately discharged by the body.
Study Results:
This process has been shown to be a common factor in the follicle health of men experiencing hair loss. This study sought to determine the effect Propecia has on the levels of Caspases (proteases that cause hair cells to die - Apoptosis), versus levels of chemicals which inhibit this process, called XIAP and FLIP.
Before taking Propecia, there was an increase in Caspases (cell death initiators) and a decrease in XIAP (cell preservation chemicals). After taking Propecia for 6 months, both Caspase and XIAP levels had returned to that of a normal human being not experiencing hair loss. Further, they sought to show exactly how caspases affect the hair follicle, and it was shown that once initiated, the process of cell death affects many functions related to haiir growth, including keratinocytes, melanocytes, the dermal papilla, and derma fibroblasts.
Conclusions:
The use of Propecia effectively eliminates the processes leading to cell death in follicular functioning, and promotes anagen, active growth in the hair cycle.
- For more information on Propecia, view our Propecia Product Review
- Discuss Propecia with others: Antiandrogen Forums
- Looking to buy Propecia online? Propecia Shop
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