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The Absence of real Data
When a product is used for so many purposes, such as MSM, (used for inflammation, arthritis, blood circulation, scar tissue, etc,) it is best to review any human and animal studies that may have been done. It’s really tough to assess hair brilliance, as this is so subjective, but at least they could have done hair counts by macro photography, which is really the way to go these days, and it wouldn’t cost that much. If they could test it in the appropriate “accepted methods” which hair studies are done today, and they prove to be positive, imagine how much money they could really make?
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The website suggests doses of 1,000 mg taken by mouth, three times a day with meals. It is stated that MSM is non-toxic at extremely high doses, but it is best to review how this was assessed and what animal toxicity studies were done. I wouldn’t suggest taking doses this high unless I really did some investigative homework to know all toxicology that has been done in human and animal studies.
MSM may help, however...
From my past research experience, it is true that there are many enzymes in skin that are important for adding sulfur and taking sulfur away from hormones and proteins, such as the keratins. During my doctoral years of studying the male-hormone enzymes that convert testosterone to dihydrotestosterone (DHT) and other pathways, there are sulfhydryl-oxidizing and reducing enzymes that make the hormones water soluble to be transported in the blood. There are a lot of sulfhydryl bonds in hair fiber, and keratin-proteins which make-up hair. The sulfur mediating enzymes and their pathways are so complex and not totally known.
It is doubtful that taking them by mouth will have any effect at the intracellular (inside the cell) level where they need to be to influence hair fiber growth.
Because of limited research funds, a lot of the “sulfur-mediating enzymes” story is just incomplete. We don’t really know, but it sure sounds good, and it could be possible, but it is best to have a company spend about $100,000 for some limited clinical trial testing, done by experienced physicians, in a double-blind fashion for a 6 month to 1 year period of time to really test any claims for hair growth.
Conclusion
There have been so many herbal supplements that have hit the marketplace, and for some people taking them who have hair loss, they swear they are seeing improvements. The problem is documentation. People want proof in the way of standardized photography taken by experts with controlled lighting, film exposure and film quality. Taking a snapshot, or quick digital photo just doesn’t cut the mustard.
For now, CAUTION is advised for any nutritional/herbal supplement you decide to take to treat your hair loss. For many, like biotin, they may not hurt you, but I doubt it will really help you.
Next issue will continue on herbal remedies and will discuss: Pygeum, Nettles, Green Tea, and Omega-3 Fish Oils.
Marty Sawaya MD, PhD
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