Hair Loss Treatments
Hair Loss & Alopecia Information, Support, and Treatments
Search
I want information on..
Hair Loss Pictures
"Hi All, Firstly, thanks for reading this. I hope some of you guys can point me in the right direction and I can get over this nightmare. All in all, I've never been happy wit..."
Men's Hair Loss Network
Check out the latest photo blogs from other guys treating their hair loss. Set up your own profile today!
Men's Hair Loss Network
JohnGalt
Men's Hair Loss Network
Iamthew...
Men's Hair Loss Network
finding...
Men's Hair Loss Network
dcsee1

View all Men's Hair Loss Blogs
Hair Transplant Network
Our newest members who've gone the Transplant route. See their progress graft by graft and upload your own Transplant Bio!
Men's Hair Loss Network
happyha...
Men's Hair Loss Network
timmy14...
Men's Hair Loss Network
wje9516...
Men's Hair Loss Network
Hairfor...

View the Hair Transplant Network
Women's Hair Loss Network
The newest women who have set up photo blogs in our network. Join today and share your story!
Women's Hair Loss Network
Peaches
Women's Hair Loss Network
Nukenjf...
Women's Hair Loss Network
Juliyvo...
Women's Hair Loss Network
eihughe...

View all Women's Hair Loss Blogs


Transplants Replacement
0 New posts today
0 People currently Posting »

hair loss alopecia
Hair Loss News
Alopecia hair loss Chat
0 People currently chatting »
Support Chat Schedule Find out when we are having our next chat gathering. Find out when we are having our next chat gathering.

Previous Chat Transcripts Get valuable information from previous in the in the hair loss chat room. the hair loss chat room.

Join the Chat
replacement transplants
You are here:  Home » News & Research » Hair Loss News Center » Old age thinning hair - same as Male Pattern Baldness?
Histology and hormonal activity in senescent thinning in males.
Authors:
Price V.H., Dept. of Dermatology, University of California, San Francisco
Sawaya M.E., ARATEC Clinics & University of Miami, Miami, Florida
Headington J.T., Dept. of Dermatology & Pathology, Ann Arbor, MI
Kibarian M.K., Dept. of Dermatology, George Washington University, Washington, D.C.

Study Information and Results:

Senescent thinning of the scalp hair, or thinning that occurs after age 60, is poorly understood, and it is unclear whether this is a distinct entity or part of the continuum of androgenetic alopecia (AGA).

In a previous study, young males age 18 to 30 with AGA had higher levels of 5a-reductase type 1 and 2, more androgen receptors, and lower levels of cytochrome P-450 aromatase in hair follicles in the frontal region of the scalp than in the occipital region.

This study in males age 60 years and older was designed to determine whether the histology and hormonal findings in older males with hair thinning are similar to AGA in young males. Males who experienced the first onset of scalp hair thinning after age 60 were compared to age-matched males (controls) without a history of hair thinning. Four scalp biopsies, two from the frontal and two from the occipital scalp, were obtained for horizontal sectioning and biochemical assay. Histologic findings were primarily follicular downsizing. Follicular drop out was not detected using elastic tissue staining, and there was no significant difference in number of follicles in frontal compared to occipital scalp.

Senescent thinning was indistinguishable from androgenetic alopecia in older males. Inflammatory changes were not a significant feature. Biochemical analysis for androgen receptors, 5 -reductase type 1 and 2, and aromatase, in scalp biopsies from older males showed nearly a two fold decrease in levels compared to levels in young males with AGA.

In males over 60, androgen receptor and aromatase levels were low and comparable in scalp with and without thinning in both frontal and occipital regions. The 5a -reductase type 1 and 2 levels were only slightly higher in males with thinning hair in both frontal and occipital regions, but the differences were not significant. Histologic and hormonal findings suggest that senescent thinning is a diffuse process that is histologically similar to AGA, but hormonally different and may not be entirely androgen dependent.

We hypothesize that senescent alopecia is distinct from AGA.

Summary:

Investigators found that men who lose their hair in their 20's have nearly twice as much androgen related activity going on in their scalp as men just beginning to lose hair in their 60's. This type of hair loss, known as "Senescent" thinning, therefore, is assumed to be due to much different causes than typical Male Pattern Baldness, and, with a little stretch of the imagination, could imply that at this stage in life, inhibiting hormonal processes to stop hair loss may no longer be necessary.

HLT
© HairlossTalk.com - All Rights Reserved.
The content found here is not intended as a substitute for professional medical advice.
For permission to duplicate any content, please Contact Us.
Make sure you're Subscribed to the Newsletter! We never share your info.
News Search
I want information in news on...
Sign Up
HairlossTalk Monthly Newsletter
Instant Notifications
Don't wait for the newsletter! Register to be notified as soon as we publish a new article to the News Center.
Hair Loss Alopecia
Test Article Lead In... »
Newsletter Test article 1 Newsletter Test article 1... »
transplants replacement
hair loss