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You are here:  Home » News & Research » Hair Loss News Center » New Odorless Topical Spiro Lotion
Dr. Lee and his team have produced a stable Topical Spironolactone product in the form of a lotion which does not have an offensive smell.
Topical Spironolactone? It's been firmly established that male pattern baldness is initiated by DHT attaching to the receptor sites on the hair follicles.

Get Topical Spironolactone delivered right to your door in a matter of days. Discreetly shipped, internationally.

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Genetically, only the follicles on the top of the head are encoded with the receptor sites, which explains why hair along the side of the head and in the back of the head is not lost with age. The attached DHT on the receptor site is perceived as a foreign body and the immune system begins to destroy the hair follicle, shortening the growth phase and causing the hair shaft to become progressively finer in texture. In extreme cases, only a vellus hair remains. The good news is that the follicles have the inherent capacity to mature to their former size. Encouraged with the success of Propecia (Finasteride) to reduce the amount of DHT in the scalp of patients with male pattern baldness (MPB), doctors and scientific researchers took another look at existing medications that are known to act as anti-androgens.

However, there have to be stringent criteria for an anti-androgen that can be used to combat or even reverse pattern alopecia. The ideal anti-androgen should have the following properties:

(1) It has to have potent anti-androgen activity.
(2) It should selectively prevent or successfully compete with DHT without changing testosterone levels.
(3) It should be effective topically, so it can be conveniently applied with minoxidil solutions.
(4) Even though it's easily absorbed into the skin, it should not have any systemic effects.

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That's a tall order. Surprisingly enough, there is such a medication: Spironolactone. For over thirty years Spironolactone has been used as an antihypertensive and a diuretic. More recently, it has been used to treat hirsutism (excess body hair) in women. Using Spironolactone to treat hirsutism may sound contradictory, but body hair (e.g. chest, face, axilla, pubis, etc.) is promoted by testosterone and since Spironolactone is a potent anti-androgen, it's successfully used to eliminate unwanted hair on the body.

On the top of the head, where the hair is adversely affected by DHT, Spironolactone has just the opposite effect. Spironolactone exhibits anti-androgenic effects in both males and females. Taken orally, it is such a potent anti-androgen that, although it is an effective anti-hypertensive drug, it is rarely used to treat men with hypertension because of its feminizing properties, including painful gynecomastia.

However, applied topically, Spironolactone does not have any systemic side effects. Among its other properties as an anti-androgen, Spironolactone also effectively prevents DHT from attaching to the receptor sites on the hair follicles. As a result, the follicles no longer atrophy and can mature again to their normal size. And it does so without decreasing the circulating levels of DHT in the body. By comparison, Finasteride inhibits the formation of DHT, causing troublesome side effects in many patients.

What's that Smell?

Despite its obvious potential, there have been some minor drawbacks with the use of topical Spironolactone. The Spironolactone has an inherent disagreeable mercaptan-like odor. Several people complain that after creating a topical Spiro solution themselves, an egg-like odor permeates their hair after application, which can be both embarrassing and inconvenient.

Fortunately, Dr. Lee and his team have produced a stable Topical Spironolactone product in the form of a lotion which does not have an offensive smell. We had the opportunity to speak with Dr. Lee regarding Spiro and the release of this new and improved version of Topical Spironolactone soon to come...

Get Topical Spironolactone Online here:

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HairlossTalk: Tell us about Topical Spironolactone.

Dr. Lee: Spironolactone is not a new medication at all. It's been used for decades, well over 30 years. It has been used for many purposes. It has been used as a diuretic, an antiandrogen, and it has pretty much always been administered orally - that is - taken as a tablet. For the most part it has always only been indicated for use in women because it has very potent antiandrogen properties which can cause feminization in men. However, there have been fairly recent studies dating back to the late 80's, which show that it works quite well topically and can be used by men in this fashion. Since it gets metabolized in the skin, it doesn't have the systemic side effects men would see if taking it orally. The advantage of using Spironolactone over other antiandrogens is multi-fold: It can prevent the synthesis of DHT from Testosterone, it actually blocks the androgen receptor site, so that if there is DHT around, carried by the bloodstream from the prostate or whatnot, the site is blocked.

- Read the Product Review for Men on Topical Spironolactone
- Read the Product Review for Women on Topical Spironolactone
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